1. Host defense and cell death

In our world, various pathogens—bacteria, viruses, fungi, and parasites—as well as cellular stressors constantly challenge our well-being. The innate immune system’s vigilance plays a crucial role in maintaining balance and health despite these relentless attacks. Innate immune cells, such as macrophages, neutrophils, and dendritic cells, are essential in detecting and combating these invaders.

These cells possess a diverse array of membrane-bound and cytoplasmic receptors that act as sentinels, capable of recognizing and responding to threats. Upon activation, these receptors initiate a cascade of immune responses, including the secretion of cytokines, which are pivotal in orchestrating and regulating the immune system’s actions. However, the immune response is not uniform; it varies depending on the nature of the invaders and is mediated by distinct receptors tailored to specific threats.

Our research mission is to uncover role of immune sensor (inflammasome) and cell death modulator that detect these invaders. We aim to identify and characterize these elusive marker using state-of-the-art technologies, unraveling the complex mechanisms underlying immune recognition. Through this work, we hope to expand our understanding of the innate immune system and contribute to the development of innovative therapeutic strategies.

2. Inflammsome and Immunometabolism

Inflammatory responses are fundamental defense mechanisms in organisms. However, deficiencies or dysregulations in this system—often caused by prolonged exposure to triggers—can lead to the development of various diseases, including chronic conditions.

During disease progression, inflammasomes assemble into protein complexes within the cytoplasm. Their activation triggers the production of inflammatory cytokines and programmed inflammatory cell death, processes that can ultimately compromise the body’s defense mechanisms.

Given their central role in inflammation, modulating inflammasome activity presents significant therapeutic potential for addressing chronic diseases such as obesity, diabetes, atherosclerosis, and sarcopenia.

Our research is dedicated to achieving a comprehensive understanding of inflammasome biology, with the ultimate goal of improving treatment strategies for these chronic diseases.